Vol. 6, Issue 1, Part A (2024)

Background: One of the most prevalent spinal anaesthesia adverse effects is hypotension, 15%–33%. It can harm the mother and foetus, especially if the woman has bleeding issues. Study objective: To determine if intravenous crystalloid and colloid solutions reduce haemodynamic instability during spinal anaesthesia. 
Method: A comparative, randomised, controlled, double-blind clinical experiment was done in the operating room at the Maternity and Obstetric Hospital in Duhok, Iraq, from October 1, 2023, to April 1, 2024. A study of 200 pregnant women aged ≥18 years scheduled for caesarean section under spinal anaesthesia was divided into two groups: Crystalloid (100 patients received 500 ml of preloading crystalloid Ringer solution) and Colloid (6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride injection). Additionally, ephedrine usage and nausea/vomiting were noted. 
Results: The colloid group had substantially higher mean arterial blood pressure at 3, 6, 9, 15, 20, and 25 minutes after anaesthesia induction than the crystalloid group. The colloid group had a considerably lower mean pulse rate at 6, 9, 15, 20, and 25 minutes following anaesthesia induction than the crystalloid group. The study groups had similar nausea and vomiting rates (P = 0.353 and 0.701). Figure 3 shows that fewer colloid patients got ephedrine than crystalloid individuals (P = 0.015). 
Conclusion: Colloid solutions controlled haemodynamics better than crystalloid solutions in elective spinal anaesthesia patients. Colloid solutions also adjusted ephedrine doses better. No significant difference in nausea and vomiting frequency between the two solutions.